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Michael L. Love proclus@mac.com

90B Massasoit Street, Waltham, MA 02453 781-894-2985



Education:


Brandeis University, Waltham, Massachusetts; Ph.D.; expected, May 2000

Program; Biochemistry

Thesis Advisor; Carolyn Cohen

Thesis Title; Troponin C - the calcium switch: Interactions of TnC with TnI and their role in thin

filament regulation

Purdue University, West Lafayette, Indiana; B.S.; 1992

Program; Molecular Biology

Lab Advisor; Thomas J. Smith

Honors Research Advisor; John E. Johnson

Thesis Title; Isolation of empty cow pea mosaic virus capsids for electron microscopy


Research Experience and Skills:


1992-present Protein crystallographic techniques; crystallization, data collection including

extensive synchrotron experience at CHESS and BNL, isomorphous replacement,

molecular replacement, crystallographic refinement, structural analysis


Crystallographic equipment installation, maintenance, training and support

proficiency; Elliot and Rigaku x-ray generators, R-AXIS and MAR image plates,

various CCD's, Supper and Yale mirrors


Crystallographic computing and Molecular graphics expertise; CCP4

installation and support, AmoRe, ARP, CNS_solve, DENZO, DM, Gimp, Molscript,

MOSFLM, O, PhotoShop, POVray, Povscript, Rasmol, Raster3D, Scala,

SCALEPACK, Strategy, X-PLOR, XV

Programming languages and computer operating systems including

installation, networking and maintainance proficiency; C, CGI, Fortran, HTML,

Linux, MacOS, Unix


1990-1992 Biochemical techniques; SDS-PAGE and native gels, western blot, silver and

coomassie blue staining procedures, ELISA, protein extraction, purification including

liquid chromatography with the FPLC, and density/viscosity gradient centrifugation


Technical Experience:


1998-present Supper Mirror Consultant

Boston Biomedical Research Institute, Watertown, Massachusetts

Science Applications International Corporation, Frederick, Maryland

Physical Chemistry Consultant

ACT Medical, Newton, Massachusetts



Publications:


1. Houdusse A, Love ML, Dominguez R, Grabarek Z, Cohen C.: Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into the Ca2+-switch in the calmodulin superfamily. Structure. 1997 5:1695-711.


2. Li Y, Love ML, Putkey JA, Cohen, C.: Bepridil opens the regulatory N-terminal lobe of cardiac troponin C. PNAS 97:5140-5145. (2000)


3. Love ML, Grabarek Z, Cohen C.: The crystal structure of troponin C complexed with troponin I peptide (96-123). (manuscript in preparation).


Additional Experience:


1983-1990 ATSCO Products Inc., Phoenix, Arizona; Expertise in all aspects of hydraulic systems

remanufacture, Recognized for technical contributions including quality control

improvements, operational and retooling design


Service:


1981-1983 Missionary work; Philadelphia, PA.


1977-1983 Military training; Coast Guard Reserve; Graduated with distinction; Yorktown Training

Center.