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Michael L. Love
proclus@gnu-darwin.org, 607-255-9386
Department of Molecular Biology and Genetics
209 Biotechnology Bldg., Cornell University, Ithaca, NY 14853 
 

Education:

Cornell University, Ithaca, New York; Postdoctoral Associate; August 2000 - present
Department; Molecular Biology and Genetics/MacCHESS
Lab Advisor; Quan Hao

Brandeis University, Waltham, Massachusetts; Ph.D.; May 2000
Program; Biochemistry
Thesis Advisor; Carolyn Cohen
Thesis Title; Troponin C - the calcium switch: Interactions of TnC with TnI and their role in thin filament regulation

Purdue University, West Lafayette, Indiana; B.S.; 1992
Program; Molecular Biology
Lab Advisor; Thomas J. Smith
Honors Research Advisor; John E. Johnson
Thesis Title; Isolation of empty cow pea mosaic virus capsids for electron microscopy


Research Experience and Skills:

2000-present Exceptional ongoing support for crystallographic stations on synchrotron beamlines; Experimental, maintenance, and user support, Quantum 4 and 210 CCDs, gigabit network clusters, terabyte arrays, parallel computation, practical data acquisition and processing mastery

1992-present Protein crystallographic techniques; crystallization, data collection including extensive synchrotron experience at CHESS and BNL, MAD, SAD, SIR, MIR, MR, NCS and multi-crystal averaging, crystallographic refinement, structural analysis

Crystallographic equipment installation, maintenance, training and support proficiency; Elliot and Rigaku x-ray generators, R-AXIS and MAR image plates, various CCD's, Supper, Yale, and Osmic mirrors

Crystallographic computing and Molecular graphics expertise; CCP4 installation and support, AmoRe, ARP, CNS_solve, DENZO, DM, DPS, Gimp, ImageMagick, Molscript, MOSFLM, O, POVray, Povscript, PyMOL, Rasmol, Raster3D, Refmac, Scala, SCALEPACK, Strategy, XDS, X-PLOR

Programming languages and computer operating systems including installation, networking and maintainance proficiency; C, CGI, Fortran, HTML, Linux, MacOS, Unix

1990-1992 Biochemical techniques; SDS-PAGE and native gels, western blot, silver and coomassie blue staining procedures, ELISA, protein extraction, purification including liquid chromatography with the FPLC, and density/viscosity gradient centrifugation
 

Technical Experience:
2001-present OpenBSD secure firewall design and maintenance proficiency;
PF, IPF, NAT, NMAP, PGP, SSH including agents and tunneling, src, ports

2001-present The Darwin Collection; editor
This encyclopedic software collection finally brings the world of free Unix software to Mac OS.

2000-present The GNU-Darwin Distribution; founder, lead developer
A Unix distribution advancing supercomputing and an alternative user interface for Apple computers, www.gnu-darwin.org.

1998-present Supper Mirror Consultant
Boston Biomedical Research Institute, Watertown, Massachusetts
Science Applications International Corporation, Frederick, Maryland

1997-present Physical Chemistry Consultant
ACT Medical, Newton, Massachusetts


Publications:

1. Houdusse A, Love ML , Dominguez R, Grabarek Z, CohenC.: Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into the Ca2+-switch in the calmodulin superfamily. Structure. 1997 5:1695-711.

2. Li Y, Love ML , Putkey JA, Cohen, C.: Bepridil opens the regulatory N-terminal lobe of cardiac troponin C. PNAS 2000 97:5140-5145.

3. Love ML, Szebenyi DME, Kriksunov IA, Munshi C, Graeff R, Lee HC, Thiel DJ.: ADP-ribosyl cyclase: crystal structures reveal a covalent intermediate. 2003 (submitted).

4. Love ML.: Parallel methods for protein crystallographic science (work in progress).


Additional Experience:

1983-1990 ATSCO Products Inc., Phoenix, Arizona; Expertise in all aspects of hydraulic systems remanufacture, Recognized for technical contributions including quality control
improvements, operational and retooling design


Service:

1981-1983 Missionary work; Philadelphia, PA.

1977-1983 Military training; Coast Guard Reserve; Graduated with distinction; Yorktown Training Center.

 
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