Michael L. Love
proclus@gnu-darwin.org, 607-255-9386
Department of Molecular Biology and Genetics
209 Biotechnology Bldg., Cornell University, Ithaca,
NY 14853
Education:
Cornell University, Ithaca, New York;
Postdoctoral Associate; August 2000 - present
Department; Molecular Biology and Genetics/MacCHESS
Lab Advisor; Quan Hao
Brandeis University, Waltham, Massachusetts; Ph.D.;
May 2000
Program; Biochemistry
Thesis Advisor; Carolyn Cohen
Thesis Title; Troponin
C - the calcium switch: Interactions of TnC with TnI and their role in
thin filament regulation
Purdue University, West Lafayette, Indiana; B.S.;
1992
Program; Molecular Biology
Lab Advisor; Thomas J. Smith
Honors Research Advisor; John E. Johnson
Thesis Title; Isolation of empty cow pea mosaic virus
capsids for electron microscopy
Research Experience and Skills:
2000-present Exceptional ongoing support for crystallographic stations on synchrotron beamlines; Experimental, maintenance, and user support, Quantum 4 and 210 CCDs, gigabit network clusters, terabyte arrays, parallel computation, practical data acquisition and processing mastery
1992-present Protein crystallographic techniques;
crystallization, data collection including
extensive synchrotron experience at CHESS and BNL, MAD, SAD, SIR, MIR, MR, NCS and multi-crystal averaging, crystallographic refinement, structural
analysis
Crystallographic equipment installation, maintenance,
training and support
proficiency; Elliot and Rigaku x-ray generators,
R-AXIS and MAR image plates,
various CCD's, Supper, Yale, and Osmic mirrors
Crystallographic computing and Molecular graphics expertise;
CCP4
installation and support, AmoRe, ARP, CNS_solve, DENZO,
DM, DPS, Gimp, ImageMagick,
Molscript, MOSFLM, O, POVray, Povscript, PyMOL, Rasmol, Raster3D,
Refmac, Scala,
SCALEPACK, Strategy, XDS, X-PLOR
Programming languages and computer operating systems
including
installation, networking and maintainance proficiency;
C, CGI, Fortran, HTML,
Linux, MacOS, Unix
1990-1992 Biochemical techniques; SDS-PAGE and
native gels, western blot, silver and
coomassie blue staining procedures, ELISA, protein extraction,
purification including liquid chromatography with the FPLC, and density/viscosity
gradient centrifugation
Technical Experience:
2001-present OpenBSD secure firewall design and maintenance proficiency;
PF, IPF, NAT, NMAP, PGP, SSH including agents and tunneling, src, ports
2001-present The Darwin Collection; editor This encyclopedic software collection finally brings the world of free Unix software to Mac OS.
2000-present The GNU-Darwin Distribution; founder, lead developer A Unix distribution advancing supercomputing and an alternative user interface for Apple computers, www.gnu-darwin.org.
1998-present Supper Mirror Consultant
Boston Biomedical Research Institute, Watertown, Massachusetts
Science Applications International Corporation, Frederick,
Maryland
1997-present Physical Chemistry Consultant
ACT Medical, Newton, Massachusetts
Publications:
1. Houdusse A, Love
ML , Dominguez R, Grabarek Z, CohenC.: Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into
the Ca2+-switch in the calmodulin superfamily. Structure. 1997 5:1695-711.
2. Li Y, Love
ML , Putkey JA, Cohen, C.: Bepridil opens the regulatory N-terminal
lobe of cardiac troponin C. PNAS 2000 97:5140-5145.
3. Love ML, Szebenyi DME, Kriksunov IA, Munshi C, Graeff R, Lee HC, Thiel DJ.: ADP-ribosyl cyclase: crystal structures reveal a covalent intermediate. 2003 (submitted).
4. Love ML.: Parallel methods for protein crystallographic science (work in progress).
Additional Experience:
1983-1990 ATSCO Products Inc., Phoenix, Arizona;
Expertise in all aspects of hydraulic systems remanufacture, Recognized for technical contributions
including quality control
improvements, operational and retooling design
Service:
1981-1983 Missionary work; Philadelphia, PA.
1977-1983 Military training; Coast Guard Reserve; Graduated
with distinction; Yorktown Training Center.
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